Package: Surrogate
Type: Package
Title: Evaluation of Surrogate Endpoints in Clinical Trials
Version: 3.4.2.9000
Authors@R: c(
  person("Wim", "Van Der Elst", email = "wim.vanderelst@gmail.com", role = c("cre", "aut")),
  person("Florian", "Stijven", email = "florian.stijven@kuleuven.be", role = "aut"),
  person("Fenny", "Ong", role = "aut"),
  person("Dries", "De Witte", role = "aut"),
  person("Gokce", "Deliorman", role = "aut"),
  person("Paul", "Meyvisch", role = "aut"),
  person("Alvaro", "Poveda", role = "aut"),
  person("Ariel", "Alonso", role = "aut"),
  person("Hannah", "Ensor", role = "aut"),
  person("Christoper", "Weir", role = "aut"),
  person("Geert", "Molenberghs", role = "aut")
  )
Description: In a clinical trial, it frequently occurs that the most
        credible outcome to evaluate the effectiveness of a new therapy
        (the true endpoint) is difficult to measure. In such a
        situation, it can be an effective strategy to replace the true
        endpoint by a (bio)marker that is easier to measure and that
        allows for a prediction of the treatment effect on the true
        endpoint (a surrogate endpoint). The package 'Surrogate' allows
        for an evaluation of the appropriateness of a candidate
        surrogate endpoint based on the meta-analytic,
        information-theoretic, and causal-inference frameworks. Part of
        this software has been developed using funding provided from
        the European Union's Seventh Framework Programme for research,
        technological development and demonstration (Grant Agreement no
        602552), the Special Research Fund (BOF) of Hasselt University
        (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland
        Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative
        Medicine.
Imports: MASS, lattice, latticeExtra, survival, nlme, lme4, logistf,
        rms, ks, extraDistr, pbapply, flexsurv, rvinecopulib, maxLik,
        purrr, MBESS, tidyr, dplyr, tibble, lifecycle, fastmatrix,
        mratios, Matrix
Depends: R (>= 3.5.0)
License: GPL (>= 2)
NeedsCompilation: no
RoxygenNote: 7.3.3
Encoding: UTF-8
LazyData: true
Suggests: copula, FNN, mgcv, testthat (>= 3.0.0), vdiffr, parallel,
        fitdistrplus, kdecopula, cubature, mvtnorm, withr, stringr,
        ggplot2, sn, pracma
Config/testthat/edition: 3
Roxygen: list(markdown = TRUE)
URL: https://github.com/florianstijven/Surrogate-development
BugReports: https://github.com/florianstijven/Surrogate-development/issues
Config/pak/sysreqs: cmake make libicu-dev libjpeg-dev libpng-dev
        libuv1-dev libx11-dev zlib1g-dev
Repository: https://florianstijven.r-universe.dev
Date/Publication: 2026-10-05 07:09:10 UTC
RemoteUrl: https://github.com/florianstijven/surrogate-development
RemoteRef: HEAD
RemoteSha: 545a4f611c6906a881c156ef47ab123da0f8e959
Packaged: 2026-10-05 07:27:24 UTC; root
Author: Wim Van Der Elst [cre, aut],
  Florian Stijven [aut],
  Fenny Ong [aut],
  Dries De Witte [aut],
  Gokce Deliorman [aut],
  Paul Meyvisch [aut],
  Alvaro Poveda [aut],
  Ariel Alonso [aut],
  Hannah Ensor [aut],
  Christoper Weir [aut],
  Geert Molenberghs [aut]
Maintainer: Wim Van Der Elst <wim.vanderelst@gmail.com>